Methylamine → HCID 68966317, compound

HRID 2116336Notes

Reaction equation

HRID 2116336 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:28])[CH:20]=[C:21]([C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:29][NH2:30]>>[F:28][C:19]1[CH:20]=[C:21]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)[C:15]2[O:14][CH:13]([CH2:12][NH:30][CH3:29])[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599302HCID 86599302, compound

Product 1

HCID 68966317HCID 68966317, compound

Procedure

The title compound was prepared (0.056 g, 34%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[5-fluoro-7-pyridin-3-yl-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.20 g, 0.50 mmol) and methylamine (0.155 g, 5.0 mmol). mp 255-257° C.

Sources & evidence

ORD record
ord-f3f950d97ff74a31b63cf67faede9cc3
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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