Methylamine → HCID 15941781, compound

HRID 2116340Notes

Reaction equation

HRID 2116340 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([Cl:30])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=4[F:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:31][NH2:32]>>[Cl:30][C:19]1[CH:20]=[C:21]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:23]=2[F:29])[C:15]2[O:14][CH:13]([CH2:12][NH:32][CH3:31])[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599305HCID 86599305, compound

Product 1

HCID 15941781HCID 15941781, compound

Procedure

The title compound was prepared (0.068 g, 60%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[5-chloro-7-(2,3-difluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.148 g, 0.329 mmol) and methylamine (0.102 g, 3.29 mmol). mp 177-179° C.

Sources & evidence

ORD record
ord-dd7f82affcd54b13baed4a67ac0692ca
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

Loading…