Methylamine → HCID 68961665, compound

HRID 2116349Notes

Reaction equation

HRID 2116349 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([Cl:31])[CH:20]=[C:21]([C:22]4[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=4[O:29][CH3:30])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:32][NH2:33]>>[Cl:31][C:19]1[CH:20]=[C:21]([C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=2[O:29][CH3:30])[C:15]2[O:14][CH:13]([CH2:12][NH:33][CH3:32])[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599314HCID 86599314, compound

Product 1

HCID 68961665HCID 68961665, compound

Procedure

The title compound was prepared (0.027 g, 21%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[5-chloro-7-(5-chloro-2-methoxyphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.165 g, 0.34 mmol) and methylamine (0.107 g, 3.4 mmol). mp 193-195° C.

Sources & evidence

ORD record
ord-3dc48825c1cc43b0a8b9b077a41773ad
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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