Methylamine → HCID 68966548, compound

HRID 2116350Notes

Reaction equation

HRID 2116350 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([Cl:30])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:31][NH2:32]>>[Cl:30][C:19]1[CH:20]=[C:21]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=2)[C:15]2[O:14][CH:13]([CH2:12][NH:32][CH3:31])[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599315HCID 86599315, compound

Product 1

HCID 68966548HCID 68966548, compound

Procedure

The title compound was prepared (0.09 g, 79%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[5-chloro-7-(3,4-difluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.149 g, 0.33 mmol) and methylamine (0.102 g, 3.3 mmol). mp 235-237° C.

Sources & evidence

ORD record
ord-85268a68cd0e414da9d9e3e4e5108d32
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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