Methylamine → HCID 68964502, compound

HRID 2116351Notes

Reaction equation

HRID 2116351 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([CH3:29])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[F:28])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[F:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=2[CH:18]=[C:19]([CH3:29])[CH:20]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599316HCID 86599316, compound

Product 1

HCID 68964502HCID 68964502, compound

Procedure

The title compound was prepared (0.03 g, 28%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2-fluorophenyl) 5-methyl-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.14 g, 0.34 mmol) and methylamine (0.105 g, 3.4 mmol). mp 153-155° C.

Sources & evidence

ORD record
ord-b8d5274e92ce49f19a7fb85b057b9102
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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