Methylamine → HCID 68964098, compound

HRID 2116356Notes

Reaction equation

HRID 2116356 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([CH3:29])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[CH3:28][C:25]1[CH:26]=[CH:27][C:22]([C:21]2[C:15]3[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=3[CH:18]=[C:19]([CH3:29])[CH:20]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599321HCID 86599321, compound

Product 1

HCID 68964098HCID 68964098, compound

Procedure

The title compound was prepared (0.049 g, 44%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(4-methylphenyl) 5-methyl-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.15 g, 0.37 mmol) and methylamine (0.114 g, 3.7 mmol). mp 184-185° C.

Sources & evidence

ORD record
ord-5b6d914fb72a4cd68786c43984a8f58f
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

Loading…