Methylamine → HCID 68967983, compound

HRID 2116357Notes

Reaction equation

HRID 2116357 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([CH3:29])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([C:21]2[C:15]3[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=3[CH:18]=[C:19]([CH3:29])[CH:20]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599322HCID 86599322, compound

Product 1

HCID 68967983HCID 68967983, compound

Procedure

The title compound was prepared (0.026 g, 21%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(4-chlorophenyl) 5-methyl-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.16 g, 0.37 mmol) and methylamine (0.115 g, 3.7 mmol). mp 210-213° C.

Sources & evidence

ORD record
ord-87bebc751e4a45d290384fadb5bdbafa
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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