Methylamine → HCID 68961119, compound

HRID 2116360Notes

Reaction equation

HRID 2116360 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([CH3:32])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:23]=4[O:30][CH3:31])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:33][NH2:34]>>[CH3:31][O:30][C:23]1[C:24]([O:28][CH3:29])=[CH:25][CH:26]=[CH:27][C:22]=1[C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:34][CH3:33])[CH2:17][C:16]=2[CH:18]=[C:19]([CH3:32])[CH:20]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599325HCID 86599325, compound

Product 1

HCID 68961119HCID 68961119, compound

Procedure

The title compound was prepared (0.094 g, 44%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2,3-dimethoxyphenyl) 5-methyl-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.18 g, 0.40 mmol) and methylamine (0.123 g, 4.0 mmol). mp 85-89° C.

Sources & evidence

ORD record
ord-7b46f36f31b64ace897df19bb46c0ed3
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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