Methylamine → HCID 11961219, compound

HRID 2116365Notes

Reaction equation

HRID 2116365 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[O:15][CH:14]([CH2:17]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:13][C:12]=2[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=1.[CH3:31][NH2:32]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[O:15][CH:14]([CH2:17][NH:32][CH3:31])[CH2:13][C:12]=2[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599330HCID 86599330, compound

Product 1

HCID 11961219HCID 11961219, compound

Procedure

The title compound was prepared (0.039 g, 51%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2-fluorophenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.102 g, 0.24 mmol) and methylamine (0.074 g, 2.4 mmol). mp 110-112° C.

Sources & evidence

ORD record
ord-28e0b1c5b5714081a82ad67c4bb43e51
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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