Methylamine → HCID 11961221, compound

HRID 2116367Notes

Reaction equation

HRID 2116367 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[O:15][CH:14]([CH2:17]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:13][C:12]=2[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=1.[CH3:31][NH2:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[O:15][CH:14]([CH2:17][NH:32][CH3:31])[CH2:13][C:12]=2[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599332HCID 86599332, compound

Product 1

HCID 11961221HCID 11961221, compound

Procedure

The title compound was prepared (0.055 g, 54%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2-methylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.135 g, 0.32 mmol) and methylamine (0.099 g, 3.2 mmol). mp 167-169° C.

Sources & evidence

ORD record
ord-c2821d009bce4aa69ebb269c6d44fe36
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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