Methylamine → HCID 15941919, compound

HRID 2116375Notes

Reaction equation

HRID 2116375 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[C:19]2[O:18][CH:17]([CH2:20]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:16][C:15]=2[CH:14]=[C:13]([O:32][CH3:33])[CH:12]=1.[CH3:34][NH2:35]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[C:19]2[O:18][CH:17]([CH2:20][NH:35][CH3:34])[CH2:16][C:15]=2[CH:14]=[C:13]([O:32][CH3:33])[CH:12]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599340HCID 86599340, compound

Product 1

HCID 15941919HCID 15941919, compound

Procedure

The title compound was prepared (0.032 g, 27%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2,5-dimethoxyphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.152 g, 0.32 mmol) and methylamine (0.100 g, 3.2 mmol). mp 144-145° C.

Sources & evidence

ORD record
ord-8bb7c6cd7a214f2c8dee426e36a664cb
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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