Methylamine → HCID 68966510, compound

HRID 2116376Notes

Reaction equation

HRID 2116376 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:31][CH3:32])=[C:6]([C:8]2[C:16]3[O:15][CH:14]([CH2:17]OS(C4C=CC(C)=CC=4)(=O)=O)[CH2:13][C:12]=3[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=2)[CH:7]=1.[CH3:33][NH2:34]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:31][CH3:32])=[C:6]([C:8]2[C:16]3[O:15][CH:14]([CH2:17][NH:34][CH3:33])[CH2:13][C:12]=3[CH:11]=[C:10]([O:29][CH3:30])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599341HCID 86599341, compound

Product 1

HCID 68966510HCID 68966510, compound

Procedure

The title compound was prepared (0.067 g, 58%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(5-chloro-2-methoxyphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.148 g, 0.31 mmol) and methylamine (0.097 g, 3.1 mmol). mp 169-171° C.

Sources & evidence

ORD record
ord-2e715fd9fce043e4afbea4aafa5746d6
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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