Methylamine → HCID 68961726, compound

HRID 2116377Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:17]3[O:16][CH:15]([CH2:18]OS(C4C=CC(C)=CC=4)(=O)=O)[CH2:14][C:13]=3[CH:12]=[C:11]([O:30][CH3:31])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[CH3:32][NH2:33]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:17]3[O:16][CH:15]([CH2:18][NH:33][CH3:32])[CH2:14][C:13]=3[CH:12]=[C:11]([O:30][CH3:31])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 6329Methylamine

HCID 86599342HCID 86599342, compound

Product 1

HCID 68961726HCID 68961726, compound

Procedure

The title compound was prepared (0.052 g, 46%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(3-chloro-4-fluorophenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.14 g, 0.31 mmol) and methylamine (0.097 g, 3.1 mmol). mp 197-199° C.

Sources & evidence

ORD record: ord-4e3cb5e8b18d45b8ad56167c314d2b02
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435837B2

Reaction notes

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