HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}-4-methylbenzenesulfonate | HCID 86599343 | — |
| Product | (+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}methylamine | HCID 68963643 | — |
Reaction Steps
The title compound was prepared (0.076 g, 57%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2,6-dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.175 g, 0.40 mmol) and methylamine (0.12 g, 4.0 mmol). mp 170-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435837B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-a19d719097cd415d9a054a59dbfaa373 |
| Source note | uspto-grants-2008_10 |