Methylamine → (+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}methylamine

HRID 2116378Notes

Reaction equation

HRID 2116378 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:14][C:13]=2[CH:12]=[C:11]([O:30][CH3:31])[CH:10]=1.[CH3:32][NH2:33]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18][NH:33][CH3:32])[CH2:14][C:13]=2[CH:12]=[C:11]([O:30][CH3:31])[CH:10]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599343(+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}-4-methylbenzenesulfonate

Product 1

HCID 68963643(+/-)-{[7-(2,6-Dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}methylamine

Procedure

The title compound was prepared (0.076 g, 57%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2,6-dimethylphenyl)-5-methoxy-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.175 g, 0.40 mmol) and methylamine (0.12 g, 4.0 mmol). mp 170-172° C.

Sources & evidence

ORD record
ord-a19d719097cd415d9a054a59dbfaa373
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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