Methylamine → HCID 68961844, compound

HRID 2116388Notes

Reaction equation

HRID 2116388 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:14][C:13]=2[CH:12]=[C:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:10]=1.[CH3:36][NH2:37]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18][NH:37][CH3:36])[CH2:14][C:13]=2[CH:12]=[C:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599353HCID 86599353, compound

Product 1

HCID 68961844HCID 68961844, compound

Procedure

The title compound was prepared (0.060 g, 76%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2-methoxyphenyl)-5-phenyl-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.10 g, 0.21 mmol) and methylamine (0.30 g, 9.8 mmol). mp 140-143° C.

Sources & evidence

ORD record
ord-73fb94d0a1f54b348099bef70afc4bcc
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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