Methylamine → HCID 68964353, compound

HRID 2116389Notes

Reaction equation

HRID 2116389 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[O:16][CH:15]([CH2:18]OS(C4C=CC(C)=CC=4)(=O)=O)[CH2:14][C:13]=3[CH:12]=[C:11]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:36][NH2:37]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[O:16][CH:15]([CH2:18][NH:37][CH3:36])[CH2:14][C:13]=3[CH:12]=[C:11]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599354HCID 86599354, compound

Product 1

HCID 68964353HCID 68964353, compound

Procedure

The title compound was prepared (0.053 g, 67%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(3-methoxyphenyl)-5-phenyl-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.10 g, 0.21 mmol) and methylamine (0.30 g, 9.8 mmol). mp 206-209° C.

Sources & evidence

ORD record
ord-b0d4cc4ec3674a67bca08c7390dfd04f
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

Loading…