Methylamine → HCID 68961422, compound

HRID 2116391Notes

Reaction equation

HRID 2116391 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18]OS(C3C=CC(C)=CC=3)(=O)=O)[CH2:14][C:13]=2[CH:12]=[C:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:10]=1.[CH3:36][NH2:37]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:17]2[O:16][CH:15]([CH2:18][NH:37][CH3:36])[CH2:14][C:13]=2[CH:12]=[C:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:10]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599356HCID 86599356, compound

Product 1

HCID 68961422HCID 68961422, compound

Procedure

The title compound was prepared (0.047 g, 59%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-{[7-(2,4-difluorophenyl)-5-phenyl-2,3-dihydro-1-benzofuran-2-yl]methyl}4-methylbenzenesulfonate (0.10 g, 0.20 mmol) and methylamine (0.30 g, 9.8 mmol). mp 188-191° C.

Sources & evidence

ORD record
ord-8223cf83a9b94b13b14af6ecef153a98
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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