Methylamine → HCID 69108791, compound

HRID 2116392Notes

Reaction equation

HRID 2116392 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:28]([F:31])([F:30])[F:29])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:32][NH2:33]>>[CH3:32][NH:33][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[C:19]([C:28]([F:31])([F:30])[F:29])[CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599357HCID 86599357, compound

Product 1

HCID 69108791HCID 69108791, compound

Procedure

The title compound was prepared (0.031 g, 67%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-phenyl-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.060 g, 0.13 mmol) and methylamine (0.12 g, 3.9 mmol). mp 189-190° C.

Sources & evidence

ORD record
ord-0052f9c9f245414ea213631794013982
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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