Methylamine → HCID 11961124, compound

HRID 2116396Notes

Reaction equation

HRID 2116396 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:30]([F:33])([F:32])[F:31])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:34][NH2:35]>>[CH3:34][NH:35][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[C:19]([C:30]([F:33])([F:32])[F:31])[CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=3)[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599361HCID 86599361, compound

Product 1

HCID 11961124HCID 11961124, compound

Procedure

The title compound was prepared (0.035 g, 48%) following the general procedure of Example 390 as a white solid, hydrochloride salt from [7-(3,4-difluorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.093 g, 0.19 mmol) and methylamine (0.12 g, 3.9 mmol). mp 235-237° C.

Sources & evidence

ORD record
ord-981994bb6f864a8e9a28dff5392f0d8f
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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