Methylamine → HCID 11961125, compound

HRID 2116399Notes

Reaction equation

HRID 2116399 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:30]([F:33])([F:32])[F:31])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[C:24]([Cl:29])[CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:34][NH2:35]>>[Cl:29][C:24]1[CH:23]=[C:22]([C:21]2[C:15]3[O:14][CH:13]([CH2:12][NH:35][CH3:34])[CH2:17][C:16]=3[CH:18]=[C:19]([C:30]([F:33])([F:32])[F:31])[CH:20]=2)[CH:27]=[CH:26][C:25]=1[F:28]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599364HCID 86599364, compound

Product 1

HCID 11961125HCID 11961125, compound

Procedure

The title compound was prepared (0.014 g, 19%) following the general procedure of Example 390 as a white solid, hydrochloride salt from [7-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.095 g, 0.19 mmol) and methylamine (0.12 g, 3.9 mmol). mp 229-230° C.

Sources & evidence

ORD record
ord-e79c2d0288e142eca5a114359f764bbb
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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