Methylamine → HCID 11961123, compound

HRID 2116400Notes

Reaction equation

HRID 2116400 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:32]([F:35])([F:34])[F:33])[CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=4[O:30][CH3:31])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:36][NH2:37]>>[CH3:36][NH:37][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[C:19]([C:32]([F:35])([F:34])[F:33])[CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=3[O:30][CH3:31])[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599365HCID 86599365, compound

Product 1

HCID 11961123HCID 11961123, compound

Procedure

The title compound was prepared (0.048 g, 76%) following the general procedure of Example 390 as a white solid, hydrochloride salt from [7-(2,4-dimethoxyphenyl)-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.080 g, 0.16 mmol) and methylamine (0.12 g, 3.9 mmol). mp 234-236° C.

Sources & evidence

ORD record
ord-0fd96059c7634948a0c8c967bc2f0734
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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