Methylamine → HCID 86599366, compound

HRID 2116401Notes

Reaction equation

HRID 2116401 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:36]([F:39])([F:38])[F:37])[CH:20]=[C:21]([C:22]4[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:24]([C:32]([F:35])([F:34])[F:33])[CH:23]=4)[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:40][NH2:41]>>[F:29][C:28]([F:30])([F:31])[C:26]1[CH:27]=[C:22]([C:21]2[C:15]3[O:14][CH:13]([CH2:12][NH:41][CH3:40])[CH2:17][C:16]=3[CH:18]=[C:19]([C:36]([F:39])([F:37])[F:38])[CH:20]=2)[CH:23]=[C:24]([C:32]([F:34])([F:33])[F:35])[CH:25]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599367HCID 86599367, compound

Product 1

HCID 86599366HCID 86599366, compound

Procedure

The title compound was prepared (0.033 g, 58%) following the general procedure of Example 390 as a white solid, hydrochloride salt from [7-[3,5-bis(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.070 g, 0.12 mmol) and methylamine (0.12 g, 3.9 mmol). mp 205-207° C.

Sources & evidence

ORD record
ord-aa103fdda28b497093a88d33ef60b676
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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