Methylamine → HCID 68964209, compound

HRID 2116405Notes

Reaction equation

HRID 2116405 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=4)[CH:20]=[C:21]([F:22])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[F:22][C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=2[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599370HCID 86599370, compound

Product 1

HCID 68964209HCID 68964209, compound

Procedure

The title compound was prepared (0.12 g, 88%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-fluoro-5-(3-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.19 g, 0.45 mmol) and methylamine (0.28 g, 9.1 mmol). mp >250° C.

Sources & evidence

ORD record
ord-03754a46ce3f4a839b0604924365ad45
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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