Methylamine → HCID 68966429, compound

HRID 2116406Notes

Reaction equation

HRID 2116406 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:23]4[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=4)[CH:20]=[C:21]([F:22])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[F:22][C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=2[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599371HCID 86599371, compound

Product 1

HCID 68966429HCID 68966429, compound

Procedure

The title compound was prepared (0.12 g, 96%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-fluoro-5-(4-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.18 g, 0.43 mmol) and methylamine (0.27 g, 8.6 mmol). mp >250° C.

Sources & evidence

ORD record
ord-01765fdeb0b94c11828f7f778157883a
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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