Methylamine → HCID 68962675, compound

HRID 2116413Notes

Reaction equation

HRID 2116413 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:30])[CH:20]=[C:21]([C:22]4[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=4[CH3:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:31][NH2:32]>CO>[CH3:29][C:23]1[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:22]=1[C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:32][CH3:31])[CH2:17][C:16]=2[CH:18]=[C:19]([F:30])[CH:20]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86599253HCID 86599253, compound

Product 1

HCID 68962675HCID 68962675, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared (0.298 g, 79%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (−)-[7-(2,6-dimethylphenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.50 g, 1.2 mmol) and methylamine (0.372 g, 12.0 mmol). [α]D25=−3.0 (c 10.0 in methanol); mp 171-173° C.

Sources & evidence

ORD record
ord-66ac649e962541e99de3cf82c5543e12
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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