反应详情

Morpholine (2.6 g) was added dropwise to a stirred solution of 4,6-dichloro-5-nitro-2-propylthiopyrimidine (8 g) and N,N-diisopropylethylamine (3.85 g) in acetonitrile (70 ml ) at 0° C. After 1 h the solvent was evaporated and the residue partitioned between ethyl acetate and water, the organics dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 25% ethyl acetate in isohexane. Yield 7.1 g

1. customAfter 1 h the solvent was evaporated
2. customthe residue partitioned between ethyl acetate and water
3. dry with materialthe organics dried (MgSO4)
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 25% ethyl acetate in isohexane