HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2116450Generated: October 30, 2026
2-Chloroaniline → N-(2-Chlorophenyl)-6-morpholin-4-yl-5-nitro-2-(propylthio)pyrimidin-4-amine
https://huagongshe.com/reaction/2116450
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloroaniline | HCID 7240 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[6-Chloro-5-nitro-2-(propylthio)pyrimidin-4-yl]morpholine | HCID 85908164 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(2-Chlorophenyl)-6-morpholin-4-yl-5-nitro-2-(propylthio)pyrimidin-4-amine | HCID 69215989 | — |
Reaction Steps
A mixture of the product from step (i) (1 g), 2-chloroaniline (0.4 g) and N,N-diisopropylethylamine (0.404 g) in isopropylalcohol (12ml) was heated at 55° C. for 14 h. The mixture was cooled and the isopropylalcohol decanted off. Yield 0.82 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07439240B2 |
|---|
| Source dataset | uspto-grants-2008_10 |
|---|
| ORD ID | ord-22609d16f9434d4c869d99e8cad105c8 |
|---|
| Source note | uspto-grants-2008_10 |
|---|
