2-Chloroaniline → N-(2-Chlorophenyl)-6-morpholin-4-yl-5-nitro-2-(propylthio)pyrimidin-4-amine

HRID 2116450Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:5]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:3]=1[N+:18]([O-:20])=[O:19].[Cl:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH2:24].C(N(CC)C(C)C)(C)C>C(O)(C)C>[Cl:21][C:22]1[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=1[NH:24][C:2]1[C:3]([N+:18]([O-:20])=[O:19])=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:5]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:7]=1

Participants

Conditions

Temperature: 55 °C

Procedure

A mixture of the product from step (i) (1 g), 2-chloroaniline (0.4 g) and N,N-diisopropylethylamine (0.404 g) in isopropylalcohol (12ml) was heated at 55° C. for 14 h. The mixture was cooled and the isopropylalcohol decanted off. Yield 0.82 g

Workup

temperatureThe mixture was cooled
customthe isopropylalcohol decanted off

Sources & evidence

ORD record: ord-22609d16f9434d4c869d99e8cad105c8
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07439240B2

Reaction notes

Loading…