反应详情

温度

100 °C

A mixture of 4-chloroaniline (1.35 g) and 2,6-dichloropurine (1 g) in n-butanol (15 ml) was heated at 100° C. for 3 h. The precipitate was filtered off, partitioned between ethyl acetate and aqueous sodium hydroxide solution, the organics dried (MgSO4), and evaporated under reduced pressure. The residue was triturated with ethyl acetate and filtered. Yield 1.04 g

1. filtrationThe precipitate was filtered off
2. custompartitioned between ethyl acetate and aqueous sodium hydroxide solution
3. dry with materialthe organics dried (MgSO4)
4. customevaporated under reduced pressure
5. customThe residue was triturated with ethyl acetate
6. filtrationfiltered