4-Chloroaniline → HCID 178478206, compound

HRID 2116453Notes

Reaction equation

HRID 2116453 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:18]=[C:17]2[C:13]([NH:14][CH:15]=[N:16]2)=[C:12](Cl)[N:11]=1>C(O)CCC>[Cl:9][C:10]1[N:18]=[C:17]2[C:13]([N:14]=[CH:15][NH:16]2)=[C:12]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:11]=1

Participants

4

Reactant 2

HCID 78124-ChloroanilineHCID 53244122,6-Dichloropurine

Product 1

HCID 178478206HCID 178478206, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-chloroaniline (1.35 g) and 2,6-dichloropurine (1 g) in n-butanol (15 ml) was heated at 100° C. for 3 h. The precipitate was filtered off, partitioned between ethyl acetate and aqueous sodium hydroxide solution, the organics dried (MgSO4), and evaporated under reduced pressure. The residue was triturated with ethyl acetate and filtered. Yield 1.04 g

Workup

  1. filtrationThe precipitate was filtered off
  2. custompartitioned between ethyl acetate and aqueous sodium hydroxide solution
  3. dry with materialthe organics dried (MgSO4)
  4. customevaporated under reduced pressure
  5. customThe residue was triturated with ethyl acetate
  6. filtrationfiltered

Sources & evidence

ORD record
ord-ab297d8bb94c4d7f96457813a0ea7078
Source dataset
uspto-grants-2008_10
Patent number
US07439240B2

Reaction notes

Loading…