p-Toluenesulfonic acid → HCID 85908186, compound

HRID 2116460Notes

Reaction equation

HRID 2116460 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH2:9][CH:10]=O)=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[N:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]2[CH:9]=[CH:10][N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 85908183HCID 85908183, compound

Product 1

HCID 85908186HCID 85908186, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product from step (ii) (2 g) and p-toluenesulfonic acid (catalytic) in methanol (30 ml) was stirred at room temperature for 2 h then evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/diethylether (2:1). Yield 0.5 g

Workup

  1. customthen evaporated under reduced pressure
  2. customThe residue was purified by chromatography on silica eluting with isohexane/diethylether (2:1)

Sources & evidence

ORD record
ord-9992896619bc41a7930254e404bffb5c
Source dataset
uspto-grants-2008_10
Patent number
US07439240B2

Reaction notes

Loading…