HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine → 4-(3-Benzenesulfonylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine | HCID 68804741 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(3-Benzenesulfonylphenyl)piperazine | HCID 9948345 | 99.2% |
Reaction Steps
A solution of 1-(3-phenylsulfonylphenyl)-4-tert-butyloxycarbonyl piperazine (D3) (96 mg, 0.23 mmol) in 1,4-dioxane (3 ml) and 4M HCl (3 ml) was refluxed at 60° C. for 1 h. The solvents were then evaporated in vacuo and the product dried under high vacuum to give a yellow solid (69 mg, 96%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07439245B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-fcec179e48cc44e1a7df1d886b7056aa |
| Source note | uspto-grants-2008_10 |