1-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine → 4-(3-Benzenesulfonylphenyl)piperazine

HRID 2116471Notes

Reaction equation

HRID 2116471 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]([N:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCOCC1.Cl>[C:1]1([S:7]([C:10]2[CH:11]=[C:12]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 688047411-(3-Phenylsulfonylphenyl)-4-tert-butyloxycarbonylpiperazine

Product 1

HCID 99483454-(3-Benzenesulfonylphenyl)piperazineYield 99.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 1-(3-phenylsulfonylphenyl)-4-tert-butyloxycarbonyl piperazine (D3) (96 mg, 0.23 mmol) in 1,4-dioxane (3 ml) and 4M HCl (3 ml) was refluxed at 60° C. for 1 h. The solvents were then evaporated in vacuo and the product dried under high vacuum to give a yellow solid (69 mg, 96%)

Workup

  1. customThe solvents were then evaporated in vacuo
  2. customthe product dried under high vacuum

Sources & evidence

ORD record
ord-fcec179e48cc44e1a7df1d886b7056aa
Source dataset
uspto-grants-2008_10
Patent number
US07439245B2

Reaction notes

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