HCID 68806544, compound → HCID 10065626, compound

HRID 2116472Notes

Reaction equation

HRID 2116472 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:22])=[O:21])[C:15]=2[Cl:29])[CH2:10][CH2:9]1)=O)(C)(C)C>O1CCOCC1>[C:23]1([S:20]([C:16]2[C:15]([Cl:29])=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH:19]=[CH:18][CH:17]=2)(=[O:21])=[O:22])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 1

HCID 68806544HCID 68806544, compound

Product 1

HCID 10065626HCID 10065626, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

4-(3-Phenylsulfonyl-2-chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester (D4A) was dissolved in 8 ml of 1,4-dioxane/4 M HCl 1:1. The mixture was heated at 60° C. for 1 h. The solvent was evaporated in vacuo to give the title product as a colourless solid.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-5148f87d54244b1fbbd9f864af24b6b1
Source dataset
uspto-grants-2008_10
Patent number
US07439245B2

Reaction notes

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