Hydrochloric Acid → HCID 69196194, compound

Participants

Reaction Steps

A stirred solution of 1,1 dimethylethyl 4-{3-[(3-chlorophenyl)carbonyl]-8-quinolinyl}-1-piperazinecarboxylate (D6) (0.15 g, 0.33 mmol) in 1,4-dioxan (3 ml) and aqueous 4 M hydrochloric acid (3 ml) was heated at 80° C. for 1.5 h under argon. The reaction mixture was concentrated in vacuo and the residue was stirred with acetone/diethyl ether (2:1)(10 ml) to afford the title compound (E2) as a yellow solid (0.126 g, 0.32 mmol, 98%).

Provenance & Evidence