Hydrochloric Acid → HCID 69196194, compound

HRID 2116519Notes

Reaction equation

HRID 2116519 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:11]=[N:12][C:13]3[C:18]([CH:19]=2)=[CH:17][CH:16]=[CH:15][C:14]=3[N:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]2)=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:11]=[N:12][C:13]3[C:18]([CH:19]=2)=[CH:17][CH:16]=[CH:15][C:14]=3[N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69196293HCID 69196293, compound

Product 1

HCID 69196194HCID 69196194, compoundYield 193.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of 1,1 dimethylethyl 4-{3-[(3-chlorophenyl)carbonyl]-8-quinolinyl}-1-piperazinecarboxylate (D6) (0.15 g, 0.33 mmol) in 1,4-dioxan (3 ml) and aqueous 4 M hydrochloric acid (3 ml) was heated at 80° C. for 1.5 h under argon. The reaction mixture was concentrated in vacuo and the residue was stirred with acetone/diethyl ether (2:1)(10 ml) to afford the title compound (E2) as a yellow solid (0.126 g, 0.32 mmol, 98%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a41ffc6fd9f34b348248c07d2d52c759
Source dataset
uspto-grants-2008_10
Patent number
US07439243B2

Reaction notes

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