Hydrochloric Acid → HCID 69195563, compound

Participants

Reaction Steps

A stirred solution of 1,1-dimethylethyl 4-[3-(phenyloxy)-8-quinolinyl]-1-piperazinecarboxylate (D8) (0.085 g, 0.21 mmol) in 1,4-dioxan (2 ml) and aqueous 4 M hydrochloric acid (2 ml) was heated at 80° C. for 2 h under argon. The reaction mixture was concentrated in vacuo to a residue which was re-evaporated with toluene (2×50 ml) to yield the title compound as a foam (0.075 g, 0.22 mmol, 100%).

Provenance & Evidence