Hydrochloric Acid → HCID 69195563, compound

HRID 2116520Notes

Reaction equation

HRID 2116520 reaction equation
[C:1]1([O:7][C:8]2[CH:9]=[N:10][C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:31]>O1CCOCC1>[ClH:31].[C:1]1([O:7][C:8]2[CH:9]=[N:10][C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69196157HCID 69196157, compound

Product 1

HCID 69195563HCID 69195563, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of 1,1-dimethylethyl 4-[3-(phenyloxy)-8-quinolinyl]-1-piperazinecarboxylate (D8) (0.085 g, 0.21 mmol) in 1,4-dioxan (2 ml) and aqueous 4 M hydrochloric acid (2 ml) was heated at 80° C. for 2 h under argon. The reaction mixture was concentrated in vacuo to a residue which was re-evaporated with toluene (2×50 ml) to yield the title compound as a foam (0.075 g, 0.22 mmol, 100%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo to a residue which
  2. customwas re-evaporated with toluene (2×50 ml)

Sources & evidence

ORD record
ord-3520b8eb3efb4031a647e3aea727f55d
Source dataset
uspto-grants-2008_10
Patent number
US07439243B2

Reaction notes

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