HCID 9948021, compound → HCID 9795116, compound

HRID 2116532Notes

Reaction equation

HRID 2116532 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:15]=[C:16](Cl)[CH:17]=[N:18][CH:19]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]>CO.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:19]=[N:18][CH:17]=[CH:16][CH:15]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

4

Reactant 1

HCID 9948021HCID 9948021, compound

Product 1

HCID 9795116HCID 9795116, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of the product from Example 1 (101 mg, 0.344 mmol) in MeOH (4 mL) was added a catalytic amount of palladium on carbon. The flask was evacuated of air and placed under a balloon of hydrogen gas. After 1 hr, the mixture was filtered through Celite® and the filtrate was evaporated to provide 85 mg of the title compound (96%).

Workup

  1. customThe flask was evacuated of air
  2. filtrationthe mixture was filtered through Celite®
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-be936f3668a84a2f9b49807acfb5a175
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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