o-Toluenesulfonyl chloride, 5-nitro- → HCID 9957288, compound

HRID 2116536Notes

Reaction equation

HRID 2116536 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:15]=[C:16]([Cl:20])[CH:17]=[N:18][CH:19]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8].[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][C:23]=1[S:31](Cl)(=[O:33])=[O:32]>>[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][C:23]=1[S:31]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:15]=[C:16]([Cl:20])[CH:17]=[N:18][CH:19]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 8457o-Toluenesulfonyl chloride, 5-nitro-HCID 9948021HCID 9948021, compound

Product 1

HCID 9957288HCID 9957288, compoundYield 89%

Procedure

The title compound was prepared using the procedure described in Example 3, beginning with 0.1 g of the aniline of Example 1 and 2-methyl-5-nitrobenzenesulfonyl chloride and adding poly(4-vinylpyridine) (250 mg, 60 mesh) to the reaction mixture. After workup, 0.15 g (89%) of the title sulfonamide was obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5f33d16f31214995adcee71c5f4c5170
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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