2,4-Dichloro-6-methylbenzenesulfonyl chloride → HCID 9849404, compound

HRID 2116538Notes

Reaction equation

HRID 2116538 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:15]=[C:16]([Cl:20])[CH:17]=[N:18][CH:19]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8].[Cl:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[S:30](Cl)(=[O:32])=[O:31]>N1C=CC=CC=1>[Cl:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[S:30]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:13][C:14]2[CH:15]=[C:16]([Cl:20])[CH:17]=[N:18][CH:19]=2)=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:32])=[O:31]

Participants

4

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 9948021HCID 9948021, compound

Product 1

HCID 9849404HCID 9849404, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared using the alternative procedure described in Example 3. In this manner, 0.1 g of the aniline of Example 1 was combined with 2,4-dichloro-6-methylbenzenesulfonyl chloride and polyvinyl pyridine to provide 0.162 g (92%) of the title sulfonamide after chromatography.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-77db6b2007664705bf3d2f5f2d90a4be
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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