Lithium Hydroxide → HCID 12109357, compound

HRID 2116541Notes

Reaction equation

HRID 2116541 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([O:23][C:24]3[CH:25]=[C:26]([Cl:30])[CH:27]=[N:28][CH:29]=3)=[C:16]([CH:22]=2)[C:17]([O:19]CC)=[O:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Li+].[OH-]>CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([O:23][C:24]3[CH:25]=[C:26]([Cl:30])[CH:27]=[N:28][CH:29]=3)=[C:16]([CH:22]=2)[C:17]([OH:19])=[O:18])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 2800607HCID 2800607, compound

Product 1

HCID 12109357HCID 12109357, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a stirred solution of the product of Example 8 (81 mg, 0.170 mmol) in MeOH (3 mL) and water (1.0 mL) was added LiOH (89.6 mg, 3.74 mmol). The solution was stirred overnight and the solvent was evaporated to yield a white solid which was recrystallized from chloroform/ethanol. Isolated yield of the title compound: 46.5 mg, 61%.

Workup

  1. customthe solvent was evaporated
  2. customto yield a white solid which
  3. customwas recrystallized from chloroform/ethanol

Sources & evidence

ORD record
ord-3d523e20150147c2997da7489520bdee
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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