Benzenesulfonyl chloride, 2,4-dichloro- → HCID 22993864, compound

HRID 2116563Notes

Reaction equation

HRID 2116563 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=2[NH2:19])[CH:7]=1.[Cl:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[S:28](Cl)(=[O:30])=[O:29]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=2[NH:19][S:28]([C:22]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:21]=2[Cl:20])(=[O:30])=[O:29])[CH:7]=1

Participants

3

Reactant 2

HCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 22993850HCID 22993850, compound

Product 1

HCID 22993864HCID 22993864, compound

Procedure

Using the method of Example 17.4, 4-(3-chloro-5-pyridyloxy)-3-aminobenzotrifluoride (0.4 g) and 2,4-dichlorobenzenesulfonyl chloride ((0.38 g) were combined to provide the title compound (0.26 g), as a crystalline solid following flash chromatography and trituration with ether. mp 150-151.5° C.

Sources & evidence

ORD record
ord-71d7e6918f5743979ebdf79b7669f6b6
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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