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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2116566Generated: November 1, 2026

Potassium Carbonate → HCID 21251108, compound

https://huagongshe.com/reaction/2116566

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant2-Fluoro-5-nitrobenzotrifluorideHCID 94954—
Reactant3-Hydroxy-5-chloropyridineHCID 582305—
SolventDimethylformamideHCID 6228—
ProductHCID 21251108HCID 21251108110.2%

Reaction Conditions

Temperature60 °C

Reaction Steps

Using the method of Example 21.2, 2-fluoro-5-nitrobenzotrifluoride (5.0 g) and 3-chloro-5-hydroxypyridine (3.1 g) were combined with potassium carbonate (5.4 g) in DMF and heated overnight at 60° C. Workup gave the title compound (8.4 g) as a crude yellow solid which was used directly in the next reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07439242B2
Source datasetuspto-grants-2008_10
ORD IDord-67eba79498ce473994ecb9aaa80b3b22
Source noteuspto-grants-2008_10