Potassium Carbonate → HCID 21251108, compound

HRID 2116566Notes

Reaction equation

HRID 2116566 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[Cl:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([OH:22])[CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([O:22][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH:21]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 949542-Fluoro-5-nitrobenzotrifluorideHCID 5823053-Hydroxy-5-chloropyridine

Product 1

HCID 21251108HCID 21251108, compoundYield 110.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

Using the method of Example 21.2, 2-fluoro-5-nitrobenzotrifluoride (5.0 g) and 3-chloro-5-hydroxypyridine (3.1 g) were combined with potassium carbonate (5.4 g) in DMF and heated overnight at 60° C. Workup gave the title compound (8.4 g) as a crude yellow solid which was used directly in the next reaction.

Sources & evidence

ORD record
ord-67eba79498ce473994ecb9aaa80b3b22
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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