反应详情

1.50 g (5.0 mmol) of 3-[4-(1-naphthalenyl-oxy)butyl]-1,3-oxazolidine-2,4-dione, prepared in Step 3.1., are dissolved in a mixture of 10 ml of tetrahydrofuran and 28 ml of a 7N solution of ammonia (200 mmol) in methanol. The solution is left to react overnight at ambient temperature and then evaporated to dryness. The product is purified by chromatography on silica gel, eluting with a 97/3 mixture of dichloromethane and methanol. It is recrystallized from ethyl acetate and then washed with diethyl ether, to give 0.73 g of product in white solid form.

1. waitThe solution is left
2. customto react overnight at ambient temperature
3. customevaporated to dryness
4. customThe product is purified by chromatography on silica gel
5. washeluting with a 97/3 mixture of dichloromethane and methanol
6. customIt is recrystallized from ethyl acetate
7. washwashed with diethyl ether