7-Hydroxy-4-phenylcoumarin → HCID 19426997, compound

HRID 2116654Notes

Reaction equation

HRID 2116654 reaction equation
O[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[Br-:19].[Br-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:19][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 53574797-Hydroxy-4-phenylcoumarinHCID 12890784Triphenylphosphane dibromide

Product 1

HCID 19426997HCID 19426997, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-hydroxy-4-phenyl-2H-chromen-2-one, (5.07 g, 21.3 mmol) and triphenylphosphine dibromide (9.88 g, 23.4 mmol) were heated in a sand bath at 320-350° C. for 3 h. The cooled mixture was dissolved in dichloromethane, silica gel (150 g) was added and the mixture was evaporated. Column chromatography with hexane/EtOAc: 70:30, gave the title compound.

Workup

  1. additionsilica gel (150 g) was added
  2. customthe mixture was evaporated

Sources & evidence

ORD record
ord-7c580dce1aa542bab04958798d689237
Source dataset
uspto-grants-2008_10
Patent number
US07439260B2

Reaction notes

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