7-Hydroxy-4-phenylcoumarin → 7-Bromo-4-phenyl-2H-chromen-2-one

Participants

Reaction Steps

7-hydroxy-4-phenyl-2H-chromen-2-one, (5.07 g, 21.3 mmol) and triphenylphosphine dibromide (9.88 g, 23.4 mmol) were heated in a sand bath at 320-350° C. for 3 h. The cooled mixture was dissolved in dichloromethane, silica gel (150 g) was added and the mixture was evaporated. Column chromatography with hexane/EtOAc: 70:30, gave the title compound.

Provenance & Evidence