Triphenylphosphane dibromide → HCID 59814839, compound

HRID 2116657Notes

Reaction equation

HRID 2116657 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[C:13]([CH3:19])[C:14](O)=[CH:15][CH:16]=3)[O:11][C:10](=[O:20])[CH:9]=2)=[CH:4][CH:3]=1.[Br-:21].[Br-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:21][C:14]1[C:13]([CH3:19])=[C:12]2[C:17]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:9][C:10](=[O:20])[O:11]2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 12890784Triphenylphosphane dibromideHCID 59814860HCID 59814860, compound

Product 1

HCID 59814839HCID 59814839, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(4-fluorophenyl)-7-hydroxy-8-methyl-2-H-chromen-2-one, (4.47 g, 16.5 mol) and triphenylphosphine dibromide (7.68 g, 18.2 mmol) were heated in a sand bath at 320-350° C. for 0.5 h. The cooled mixture was dissolved in dichloromethane, silica gel was added and the mixture was evaporated. Chromatography on silica gel (hexane/EtOAC; 90:10), gave the title compound.

Workup

  1. additionsilica gel was added
  2. customthe mixture was evaporated

Sources & evidence

ORD record
ord-e6138d3851de4ebbb2c59673a1074aae
Source dataset
uspto-grants-2008_10
Patent number
US07439260B2

Reaction notes

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