HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 7-bromo-4-(bromoacetyl)-2H-chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 7-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one | HCID 23370204 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-bromo-4-(bromoacetyl)-2H-chromen-2-one | HCID 23370239 | — |
Reaction Steps
To a solution of 7-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one (2.0 g, 6.8 mmol) in THF and H2O was added N-bromosuccinimide (1.3 g, 14.2 mmol) and stirred for 30 min. Toluene was added and the solvent was evaporated. The residue was chromatographed on silica gel (hexane/EtOAc; 80:20) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07439260B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-1d54f5f05d93454299555028a2c97d0f |
| Source note | uspto-grants-2008_10 |